the same genes which provide resistance to the black death can also cause autoimmune disease

The bubonic plague killed so many people in Europe, the Middle East, and North Africa that that natural selection event is still rippling through our genomes today. But the same genes that helped your ancestors survive the Black Death may be contributing to autoimmune disease today. Hosted by: Stefan Chin (he/him) ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Alex Hackman, Ash, Bryan Cloer, charles george, Chris Mackey, Chris Peters, Christoph Schwanke, Christopher R Boucher, Eric Jensen, Harrison Mills, Jaap Westera, Jason A, Saslow, Jeffrey Mckishen, Jeremy Mattern, Kevin Bealer, Matt Curls, Michelle Dove, Piya Shedden, Rizwan Kassim, Sam Lutfi ---------- Looking for SciShow elsewhere on the internet? SciShow Tangents Podcast: https://scishow-tangents.simplecast.com/ TikTok: https://www.tiktok.com/@scishow Twitter: http://www.twitter.com/scishow Instagram: http://instagram.com/thescishow Facebook: http://www.facebook.com/scishow #SciShow #science #education #learning #complexly ---------- Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932995/ https://www.nih.gov/news-events/nih-research-matters/how-black-death-shaped-human-evolution https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580435/ https://www.ncbi.nlm.nih.gov/gene/64167 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119032/ https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1127-0 https://www.pfizer.com/news/articles/is_rheumatoid_arthritis_genetic_or_hereditary#:~:text=HLA%2DDR4%E2%80%94This%20is%20the,and%20symptoms%20may%20be%20worse https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752571/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751129/ https://medlineplus.gov/genetics/condition/multiple-sclerosis/#causes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513766/ https://www.science.org/content/article/there-are-about-20000-human-genes-so-why-do-scientists-only-study-small-fraction-them https://www.sciencedirect.com/topics/medicine-and-dentistry/antagonistic-pleiotropy https://www.nature.com/scitable/topicpage/pleiotropy-one-gene-can-affect-multiple-traits-569/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254080/ https://www.nih.gov/news-events/news-releases/nih-study-shows-genomic-variation-causing-common-autoinflammatory-disease-may-increase-resilience-bubonic-plague Image Sources: https://commons.wikimedia.org/wiki/File:Doutielt3.jpg https://tinyurl.com/43udjhk5 https://commons.wikimedia.org/wiki/File:Bubonic_plague_map_2.png https://www.gettyimages.com/detail/photo/brown-rat-in-darkness-walking-in-water-royalty-free-image/1452465372?phrase=plague+rat&adppopup=true https://www.gettyimages.com/detail/photo/pet-rat-human-skull-royalty-free-image/1264180187?phrase=black+death&adppopup=true https://www.gettyimages.com/detail/video/cemetery-graveyard-tombstones-rising-pan-scene-halloween-stock-footage/1217911769?adppopup=true https://www.gettyimages.com/detail/photo/sequence-royalty-free-image/498188318?phrase=dna+genes&adppopup=true https://www.gettyimages.com/detail/video/bases-with-deoxyribonucleic-acid-molecule-rotate-on-stock-footage/1709305492?adppopup=true https://www.gettyimages.com/detail/photo/microscope-royalty-free-image/493957253?phrase=microscope&adppopup=true https://www.gettyimages.com/detail/illustration/immune-response-and-antigen-presentation-royalty-free-illustration/1256692927?phrase=antigen+presenting+cell&adppopup=true https://www.gettyimages.com/detail/illustration/immune-system-royalty-free-illustration/884651112?phrase=immune+system&adppopup=true https://commons.wikimedia.org/wiki/File:Black_death_XV.jpg https://www.gettyimages.com/detail/photo/gastroenterology-consultation-anatomical-intestines-royalty-free-image/1401368835?phrase=Crohn%27s+disease&adppopup=true https://www.gettyimages.com/detail/video/microscopic-bacteria-medical-background-stock-footage/519456917?adppopup=true https://www.gettyimages.com/detail/video/antibodies-block-a-virus-from-entering-a-body-cell-stock-footage/1221226197?adppopup=true https://www.gettyimages.com/detail/video/colorful-dna-element-motion-stock-footage/932150052?adppopup=true https://www.gettyimages.com/detail/photo/ancient-artifacts-in-akrotiri-santorini-royalty-free-image/521801503?phrase=akrotiri&adppopup=true https://www.gettyimages.com/detail/video/virus-cells-floating-in-mid-air-3d-render-stock-footage/1212544935?adppopup=true https://www.gettyimages.com/detail/photo/stomach-pains-royalty-free-image/1412268592?phrase=crohn%27s+disease&adppopup=true https://www.gettyimages.com/detail/illustration/dna-royalty-free-illustration/484011593?phrase=dna&adppopup=true https://commons.wikimedia.org/wiki/File:Peste_bubonique_-_enluminure.jpg https://www.gettyimages.com/detail/photo/collection-set-old-parchment-paper-sheet-vintage-royalty-free-image/1438886935?phrase=medieval&adppopup=true